As drug lords Don Mario and el Cabo begin a gang war, Bu?uelo and Pirulo are jailed, and Pepe is freed on probation following his arrest in Miami.
Pepe strikes a deal with a DEA agent to avoid extradition, while Raymundo listens in on his boss's girlfriend's calls, and Juan B leaves for Colombia.
Raymundo informs his boss about his girlfriend's calls, while Don Mario plots to kill Caremotor, and Pepe threatens some thugs staked out on his land.
Don Mario searches for Caremotor, threatening anyone who might hide his prey. Pirulo talks to Luis Fernando, a Brazilian capo, about a prison escape.
After police find a stack of cash in his car, Vironcha sends his family away. Paredón plots a murder, while Mario's men target Guillo.
Pepe buys a rifle in preparation for a showdown over his land, while Pirulo readies to escape prison. Vironcha hides Paredón in a friend's house.
Peter congratulates Pepe on his informant work, while Juan B names Rocky the head of border distribution. Valderrama is delivered to the police.
Madero discovers Caremotor is sending drugs by submarine, while Pepe strikes a deal with Farid. Pirulo learns his accountant surrendered to police.
Larissa discovers her husband has a mistress, while Racines moves into el Puma's house. Madero learns Caremotor's sub coordinates.
Larissa flees Caliche's house, but he sends Antenas to find her. Police assault Caremotor at his hideout, while Pepe plans to meet with Farid.
While Madero follows Caremotor to Ecuador, Cabo instructs John to kill four informants in the U.S., and Pirulo and Luis ready to escape prison.
Their breakout a bust, Pirulo and Luis are detained in jail while Farid is arrested by the DEA. Rocky rescues Johana and her aunt from sexual assault.
Farid helps the DEA, sharing tips about Puma and Negrete. Olano clears out Pepe's ranch, while Cabo holes up in a hotel hosting a modeling contest.
In Ecuador, Madero finally catches Caremotor, while the paramilitary try to nab Puma in Colombia. Racines and Andrea continue their affair.
Caremotor is sent to Colombia for prosecution, while Zully's husband threatens her at the clinic and Cabo becomes interested in model Vicky.
In Colombia, Caremotor learns that his family was murdered by Mario's men. Puma tries to kill his wife.
Raymundo begins working with the DEA to trap Caliche, his boss, while Mario learns about Racines' affair and goes in search of his nemesis, Cabo.
Mario shows up at the modeling contest, ready to kill Cabo. Zully strikes a deal with the prosecutor to incriminate Oliver, but the dealer escapes.
Cabo flees after a shootout at a bar, Rocky and Johanna grow closer and Madero captures a key player.
Caremotor's testimony puts Pájarraco behind bars, while Zully's tips lead to Oliver's capture by the DEA. Bu?uelo's wife arranges for his jailbreak.
Pepe flees to Anestesia's place, staying one step ahead of Rocky's hitmen, while Madero worries that his partner may be involved with the traffickers.
While Andrea surrenders to the DEA to get her son back and El Pajarraco offers to become an informant, XL and Rocky recover their confiscated drugs.
El Pájarraco tells Madero and Agent Peter about Teto's and Mario's operations, while Antena reveals information on boss Caliche's drug shipments.
Plagued by stomach pain, Cabo visits his doctor, who speculates that he may have colon cancer. Pepe and Anestesia confer with the DEA agent.
Madero captures Don Teto, while Antenas aids the DEA in confiscating Caliche's merchandise in the Bahamas, and Caliche arranges to flee his home.
After Rocky confesses his love to Johana, he is captured by Mexican police and the DEA. Through their bosses, Cabo and Mario come to an agreement.
Hoping to capture El Golfo, Lilian poses as a prostitute, while XL's men kill Racines in order to keep Mario and Cabo's agreement together.
John argues with assassins Las Tres Cruces, then meets with Pepe and Anestesia. Mexican police and the DEA catch Golfo, and Pirulo is sent to the U.S.
John tries to kill Pepe, who bests him and turns him in to the DEA. Cabo, meanwhile, begs Vicky's forgiveness and Patricia decides to help the police.
Caliche learns that Raymundo is a snitch and sends him to kill Jumangi. Antenas is fired as an informant while Zully discovers her sister has escaped.
Tipped off by Anestesia, Verdugo arrests Rocky. Larissa also faces arrest and Johana is questioned, while Patricia and her husband are held prisoner.
With help from his henchmen, Caliche prepares to bust Larissa out of jail, while Johana opens up to authorities about the Mexican drug connection.
After Patricia reports agent Sam for corruption, she undergoes a life-saving operation to remove a tumor. Caliche, meanwhile, is trapped by police.
Peter hires Antenas as his DEA snitch, while Sam is removed from the Paredón operation. Cabo kills the Venezuelan thugs who had been threatening him.
Maj. Bravo's men slay May. Madero, while Paredón tries to kill Sam. Anestesia, meanwhile, helps Pepe flee Miami, and Cabo hears from his son.
Vicky discovers Cabo has been unfaithful, then meets Milton's son, while Antena plants microphones in the modeling agency. Pepe escapes to Cartagena.
In Cartagena, Pepe buys a truck using dollars recovered from his stash, while Olano learns that Amparo is out of prison. Anestesia threatens Doménico.
After being chased by the DEA, Rambo hides at Anestesia's. Pepe manages to see his daughter in the capital, while Cabo learns he has colon cancer.
Agent Sam is suspended, and Maj. Bravo is captured. Olano nabs lawyer Doménico, while Pepe meets up with Amparo's sister at a handicap center.
Olano transfers Doménico's assets to boss Amparo, while Anestesia warns Bu?uelo about the lawyer. Cabo's overseas cocaine shipment is intercepted.
Caliche gets out of prison, but Primo is captured by Venezuelan police. Cabo kills Gen. Morales' informer, while snitch Zully changes her identity.
Caliche meets with Antenas, while Oliver makes a deal concerning Paredón's whereabouts, and Milton confronts an exporter of hallucinogenic pills.
Captured by police after being attacked by Cabo's men, XL resorts to drastic measures, while Calero makes inquiries about Leo and Estupi?án's case.
While Morales learns that Cabo has returned to Colombia, thwarting his revenge plot, Oliver tries to hand over Paredón with help from his niece.
Estupi?án faces justice from his countrymen, while Calero arrests Leo. Caliche's wife, meanwhile, grows suspicious about the source of his income.
El Pariente is extradited to the U.S., and Antena feels heat from a junta snitch. Caliche, meanwhile, learns his wife took lovers in his absence.
After Vicky provides information on Cabo, Calero launches an operation against the trafficker. Pepe learns of plans to bring his daughter to Madrid.
DEA agents capture Paredón, while Rocky is freed on the condition he meet publicly with Johana. Caliche exacts his sly revenge.
While agent Sam protects Zully from a killer sent by Oliver, the senator sends an assassin to murder Caliche. Pepe is finally captured by the DEA.
Agents Katherine, Sam and Peter return home, while Pajarraco, Mario, and Bu?uelo are sentenced in Miami, and Cabo’s son and Caliche meet their fates.